Table 5.
Association of the rs1042667 and rs12601701 genotypes of SOX9 gene with the clinical phenotypes of ONFH.
| dbSNP | Genotype | Sex χ 2 test | Disease course (months) ANOVA test |
Etiological classification n (%) χ 2 test |
Unilateral or bilateral hips lesions n (%) χ 2 test |
Clinical stage n (%) χ 2 test |
||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Men n (%) |
Women n (%) |
Alc | Ster | Idio | Unilateral | Bilateral | Stage II | Stage III | Stage IV | |||
| rs1042667 |
AA | 30 (23.8) | 9 (16.1) | 86.72 + 74.80 | 19 (27.9) | 9 (20.0) | 11 (16.4) | 14 (17.7) | 25 (24.5) | 2 (15.4) | 10 (19.2) | 26 (23.2) |
| AC | 63 (50.0) | 29 (51.8) | 66.66 + 72.85 | 35 (51.5) | 25 (55.6) | 30 (44.8) | 39 (49.4) | 52 (51.0) | 8 (61.5) | 30 (57.7) | 52 (46.4) | |
| CC | 33 (26.2) | 18 (32.1) | 71.88 + 62.21 | 14 (20.6) | 11 (24.4) | 26 (38.8) | 26 (32.9) | 25 (24.5) | 3 (23.1) | 12 (23.1) | 34 (30.4) | |
| P | 0.450 | 0.332 | 0.131 | 0.352 | 0.646 | |||||||
|
| ||||||||||||
| rs12601701 |
AA | 41 (32.6) | 20 (35.7) | 65.13 + 60.99 | 22 (32.4) | 13 (28.9) | 26 (38.8) | 36 (45.6) | 25 (24.5) | 3 (23.1) | 20 (38.5) | 36 (32.2) |
| AG | 59 (46.8) | 26 (46.4) | 72.42 + 73.97 | 30 (44.1) | 23 (51.1) | 30 (44.8) | 32 (40.5) | 52 (51.0) | 7 (53.8) | 25 (48.0) | 51 (45.5) | |
| GG | 26 (20.6) | 10 (17.9) | 84.94 + 77.19 | 16 (23.5) | 9 (20.0) | 11 (16.4) | 11 (13.9) | 25 (24.5) | 3 (23.1) | 7 (13.5) | 25 (22.3) | |
| P | 0.874 | 0.411 | 0.729 | 0.009 | 0.636 | |||||||