Table 2.
Comparison of serum levels of selected cytokines and markers of disease activity in spondyloarthritis patients with and without acute anterior uveitis and inflammatory bowel disease.
| AAU present |
AAU absent |
P | IBD present |
IBD absent |
P | |
|---|---|---|---|---|---|---|
| Age (years) | 44.8 ± 12.1 | 48.9 | 0.06 | 42.6 ± 11.4 | 48.3 ± 13.1 | 0.1 |
| Disease duration (years) | 10.0 (5.0, 19.0) |
5.0 (2.0, 9.0) |
0.0002 | 10.0 (5.0, 13.5) |
5.0 (2.0, 10.) |
0.06 |
| HLA-B27 | 94.4 ± 23.5 | 47.1 | 0.0001 | 100 | 62 | 0.04 |
| VAS pain (mm) | 63.7 ± 28.3 | 49.4 ± 23.8 | 0.0008 | 67.5 ± 28.7 | 51.4 ± 24.8 | 0.03 |
| BASDAI | 5.8 ± 2.8 | 3.9 ± 2.7 | 0.0001 | 5.3 | 4.2 | 0.1 |
| ASDAS-ESR | 2.7 (2.2, 3.4) |
2.3 (1.8, 3.0) |
0.04 | 3.1 (2.2, 4.1) |
2.4 (1.8, 3.2) |
0.06 |
| DAS28 | 0.0 | 4.24 | <0.0001 | 0.0 | 4.24 | <0.0001 |
| CRP (mg/L) | 10.5 (2.6, 21.1 0) |
5.0 (2.0, 11.4) |
0.006 | 19.0 (7.8, 31.1) |
5.5 (2.1, 12.3) |
0.0009 |
| ESR (mm/h) | 14.0 (5.0, 35.) |
13.5 (6.0, 24.5) |
0.4 | 25.5 | 14.0 | 0.05 |
| IL-6 (pg/mL) | 4.5 (1.5, 10.1) |
2.9 (1.5, 6.5) |
0.02 | 3.3 (1.5, 6.4) |
2.9 (1.5, 20.7) |
0.0003 |
| IL-18 (pg/mL) | 323.5 (228.7, 454.5) |
271.8 (203.5, 346.2) |
0.03 | 333.8 (237.5, 285.2) |
271.8 (207.3, 373.9) |
0.4 |
| IL-23(pg/mL) | 0.0 (0.0, 2.8) |
0.0 (0.0, 1.8) |
0.2 | 0.0 (0.0, 0.3) |
0.0 (0.0, 2.0) |
0.2 |
| VEGF (pg/mL) | 406.2 (270.0, 880.0) |
343.1 (223.2, 545.7) |
0.05 | 341.3 (206.3, 505.0) |
347.4 (225.9, 562.2) |
0.3 |
| EGF (pg/mL) | 115.0 (62.0, 182.0) |
104.0 (68.0, 168.0) |
0.5 | 81.0 (32.0, 141.0) |
104.0 (68.0, 182.0) |
0.2 |
| ET-1 (pg/mL) | 1.1 ± 0.4 | 1.3 ± 0.6 | 0.07 | 1.3 ± 0.5 | 1.3 ± 0.5 | 0.3 |
Data are presented as mean ± standard deviation, median (Q1 and Q3). AAU: acute anterior uveitis, ASDAS-ESR: Ankylosing Spondylitis Disease Activity Score, BASDAI: Bath Ankylosing Spondylitis Disease Activity Index, CRP: C-reactive protein, DAS28: Disease Activity Score 28, EGF: epidermal growth factor, ESR: erythrocyte sedimentation rate, ET-1: endothelin-1, IBD: inflammatory bowel disease, IL-6: interleukin-6, IL-18: interleukin-18, IL-23: interleukin-23, VAS pain: visual analogue scale of patient's pain, and VEGF: vascular endothelial growth factor.