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. 2004 Sep;72(9):5412–5418. doi: 10.1128/IAI.72.9.5412-5418.2004

FIG. 2.

FIG. 2.

CIDR1α and IE induce B-cell proliferation. Proliferative (A) and TNF-α (B) production response of B cells to increasing numbers of uninfected or P. falciparum-IE. (C) Proliferative response of B cells to increasing concentrations of purified GST and CIDR1α. Values represent mean counts per minute ± SD of a representative experiment. (Inset) Summary of the proliferative response of B cells to 50 μg of GST or CIDR1α per ml. Values represent mean ± standard error of the mean of the RI in 26 independent experiments. (D) Comparison of the proliferative response of B cells to recombinant CIDR1α and DBL1α. Results are representative of three experiments; the SD bars (≤15%) have been omitted. (E) Proliferation of total B cells in response to GST or CIDR1α (50 μg/ml) previously incubated with increasing concentrations of soluble IgM. Values are expressed as percent inhibition of the proliferation of B cells in response to GST or CIDR1α preincubated in medium alone. (F) Comparative proliferative response of total, IgG-positive, and IgM-positive B cells to 50 μg of GST or CIDR1α per ml. Results are representative of five independent experiments. RBC, red blood cells.