Figure 5.

Adamdec1 deficiency results in an increased susceptibility to C. rodentium. a. Adamdec1^-/- mice demonstrate a significant reduction in total body weight from Days 8 to 13 after C. rodentium inoculation [~ 10⁹] compared with wild-type animals [n = 15 per genotype, results replicated in four further experiments, data not shown]. b. An increased level of mortality was evident in Adamdec1^-/- mice compared with wild-type animals. c. The levels of C. rodentium measured in faecal samples were similar between Adamdec1^-/- and wild-type mice as shown on Days 6 and 13. d. IL1β is significantly elevated in the serum of Adamdec1^-/- mice on Day 13 post infection compared with naïve and wild-type animals. IL-6 is significantly elevated in the serum of Adamdec1^-/- mice on Day 13 post infection compared with naïve and wild-type animals. IL10 is elevated in both Adamdec1^-/- and wild-type mice compared with naïve animals, but no difference is observed between genotypes [n = 4 per genotype, replicated in second experiment, data not shown]. Results are expressed as the mean ± standard error of the mean [SEM]. [*p < 0.05, **p < 0.01, ***p < 0.001.]