Summary statements		Agreement [score 7–9], n/N [%]
1	Ileal disease location [EL2], upper gastrointestinal [GI] involvement [EL3] and extraintestinal manifestations [EIMs] [EL3] are associated with disease progression to complicated behaviour* in CD.	66/80 [82%]
2	Younger age and perianal disease at diagnosis are associated with a disabling course of CD [EL3].	76/83 [91%]
3	Smoking predicts increased need for therapy escalation [EL3], progression to complicated disease behaviour [EL3], need for surgery [EL3] and post-operative recurrence in CD [EL3].	80/92 [87%]
4	Endoscopic severity of CD may be associated with development of penetrating complications [EL4].	73/93 [79%]
5	Serological reactivity to certain microbial antigens is associated with progression to complicated disease behaviour in paediatric and adult-onset CD [EL2]; the risk of disease evolution towards complicated forms of CD increases with the number of antibodies detected in the serum [EL2].	72/91 [79%]
6	Although mutations in some genes (such as NOD2 [EL2]) may be associated with progression to complicated CD, as yet there is no evidence for use of genetic markers in clinical practice.	92/98 [94%]

*B2/B3 behaviour.