Table 1.
Clustering of Significantly Over-represented GO Terms from a List of Genes Significantly More Highly Expressed in the Chorioallantoic Placenta Compared the Yolk Sac Placenta in P. entrecasteauxii
| GO term (biological processes) | P valuea | Benjamini corrected P value | Fold enrichment | Gene symbols in cluster |
|---|---|---|---|---|
| Organic acid transport (Cluster 1) | Enrichment Score: 4.22 | |||
| GO:0015837∼amine transport | 0.0000 | 0.00 | 17.37 | SLC38A3, AQP9, SLC6A2, SLC6A4, SLC7A8, SLC3A2, SLC22A3, SLC7A5, PDZK1, CRYM |
| GO:0046942∼carboxylic acid transport | 0.0000 | 0.00 | 11.15 | SLC38A3, SLC16A1, AQP9, AQP8, SLC7A8, SLC3A2, SLC7A5, PDZK1 |
| GO:0015849∼organic acid transport | 0.0000 | 0.00 | 11.08 | SLC38A3, SLC16A1, AQP9, AQP8, SLC7A8, SLC3A2, SLC7A5, PDZK1 |
| GO:0015804∼neutral amino acid transport | 0.0001 | 0.02 | 39.04 | SLC38A3, SLC7A8, SLC3A2, SLC7A5 |
| GO:0006865∼amino acid transport | 0.0009 | 0.10 | 11.39 | SLC38A3, SLC7A8, SLC3A2, SLC7A5, PDZK1 |
| GO:0015807∼L-amino acid transport | 0.0054 | 0.26 | 26.74 | SLC38A3, SLC7A8, SLC7A5 |
| GO:0015718∼monocarboxylic acid transport | 0.024 | 0.58 | 12.30 | SLC16A1, AQP9, AQP8 |
| Neuron-related transport (Cluster 2) | Enrichment Score: 2.36 | |||
| GO:0015844∼monoamine transport | 0.0001 | 0.01 | 48.23 | SLC6A2, SLC6A4, SLC22A3, CRYM |
| GO:0019226∼transmission of nerve impulse | 0.0014 | 0.13 | 4.69 | UNC119, CLDN19, SLC6A2, GALR3, SLC6A4, LPAR3, SLC22A3, VIPR1 |
| GO:0007268∼synaptic transmission | 0.0030 | 0.22 | 4.81 | UNC119, SLC6A2, GALR3, SLC6A4, LPAR3, SLC22A3, VIPR1 |
| GO:0006836∼neurotransmitter transport | 0.0074 | 0.29 | 9.88 | SLC6A2, SLC6A4, SLC22A3, SLC6A17 |
| GO:0007267∼cell-cell signaling | 0.025 | 0.57 | 2.73 | UNC119, SLC6A2, GALR3, SLC6A4, LPAR3, SLC22A3, VIPR1, IHH |
| Lipid metabolism (Cluster 3) | Enrichment Score: 2.09 | |||
| GO:0008202∼steroid metabolic process | 0.0004 | 0.05 | 7.10 | SDR42E2, NPC1, OSBPL3, HSD17B2, SDR42E1, SORL1, NPC1L1 |
| GO:0006869∼lipid transport | 0.033 | 0.63 | 5.65 | NPC1, OSBPL3, SORL1, NPC1L1 |
| GO:0010876∼lipid localization | 0.040 | 0.68 | 5.22 | NPC1, OSBPL3, SORL1, NPC1L1 |
| Ion transport (Cluster 4) | Enrichment Score: 1.95 | |||
| GO:0006811∼ion transport | 0.0034 | 0.21 | 2.94 | SLC12A7, SLC38A3, SLC16A1, SLC20A2, SLC9A3, CLIC6, SLC3A2, SLC22A3, ABCC4, SLC13A4, PDZK1 |
| GO:0006814∼sodium ion transport | 0.0035 | 0.20 | 7.88 | SLC12A7, SLC38A3, SLC20A2, SLC9A3, SLC13A4 |
| GO:0006820∼anion transport | 0.0049 | 0.25 | 7.17 | SLC12A7, SLC16A1, SLC20A2, CLIC6, SLC13A4 |
| GO:0055085∼transmembrane transport | 0.0057 | 0.25 | 3.24 | SLC12A7, SLC16A1, SLC25A31, AQP9, SLC9A3, SLC22A3, ABCC4, SLC13A4, PDZK1 |
| GO:0015698∼inorganic anion transport | 0.010 | 0.34 | 8.82 | SLC12A7, SLC20A2, CLIC6, SLC13A4 |
| GO:0006812∼cation transport | 0.016 | 0.48 | 2.97 | SLC12A7, SLC38A3, SLC20A2, SLC9A3, SLC3A2, SLC22A3, SLC13A4, PDZK1 |
| Steroid metabolism (Cluster 5) | Enrichment Score: 1.65 | |||
| GO:0008202∼steroid metabolic process | 0.0004 | 0.05 | 7.10 | SDR42E2, NPC1, OSBPL3, HSD17B2, SDR42E1, SORL1, NPC1L1 |
| GO:0006694∼steroid biosynthetic process | 0.0079 | 0.29 | 9.65 | SDR42E2, HSD17B2, SDR42E1, NPC1L1 |
| Cell homeostasis (Cluster 6) | Enrichment Score: 1.07 | |||
| GO:0042592∼homeostatic process | 0.0029 | 0.23 | 3.00 | SLC12A7, NPC1, GCLC, AQP9, FGGY, SLC9A3, VEGFA, TRHR, SLC7A8, LPAR3, NPC1L1 |
| GO:0048878∼chemical homeostasis | 0.0030 | 0.20 | 3.60 | NPC1, GCLC, AQP9, SLC9A3, VEGFA, TRHR, SLC7A8, LPAR3, NPC1L1 |
| Response to steroid hormones (Cluster 7) | Enrichment Score: 0.99 | |||
| GO:0006790∼sulfur metabolic process | 0.018 | 0.49 | 7.13 | GCLC, GPX4, SULF1, GHR |
| GO:0032355∼response to estradiol stimulus | 0.028 | 0.59 | 11.39 | GPX4, GHR, IHH |
| Endocytosis (Cluster 8) | Enrichment Score: 0.90 | |||
| GO:0006898∼receptor-mediated endocytosis | 0.027 | 0.59 | 11.60 | SLC9A3, SORL1, GHR |
aFor brevity, only go terms with P< 0.05 are displayed.