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(D) The frequency of SFTP gene family loss-of-function variants. This x-axis of the boxplot indicates the genes neighboring FLG. The y-axis indicates the cumulative allele frequency of loss-of-function variants affecting these genes in 1000 Genomes Phase 3 dataset populations. All the genes represented in this figure are members of the SFTP gene family and have similar gene organization with FLG, carrying large exonic repeats.
