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. 2016 Sep 27;8(10):3240–3255. doi: 10.1093/gbe/evw242

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© The Author 2016. Published by Oxford University Press on behalf of the Society for Molecular Biology and Evolution.

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact journals.permissions@oup.com

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Fig. 5.— — Putatively functional variants are linked with Huxian haplogroup. The x-axis of this plot shows the chromosomal location. The y-axis shows the LD R² between all reported single nucleotide variants in CHB population and rs77422831, which is the defining variant for Huxian haplogroup. Top panel shows the approximate locations of genes. In each panel, a different functional aspect of the variation was considered. In the top panel, the variants with CADD scores in the 90th percentile (CADD = 6.714355) were indicated with red points. In the middle panel, the variants that are significantly (P < 10⁻⁵) associated with the expression levels of HRNR were indicated with red points. In the bottom panel, the variants that are associated with skin microbiome diversity (P < 0.001) were indicated by red points.