Table 1.

Reported cases of mixed corticomedullary tumours

Reference	Age/gender	Clinical presentation	Hormones secreted	Tumour size (cm)
Mathison and Waterhouse,2 1969	39 F	Cushing syndrome, intraoperative HTN	Cortisol, ACTH*, catecholamines	4
Akai et al,3 1993	61 F	HTN, hyperglycaemia	Cortisol, ACTH*, catecholamines	3.5
Ohta et al,4 1995	32 M	Cushing syndrome, intraoperative HTN	Cortisol, ACTH*	4.5
Michal and Havlicek5 1996	56 F	Cushing syndrome, HTN	Cortisol, aldosterone, catecholamines	8
	32 F	Cushing syndrome, HTN	Cortisol, aldosterone, catecholamines	9
Wieneke et al,1 2001	34 F	HTN, hair loss, amenorrhoea	Cortisol	4.5
	52F	Flank pain	None	2.5
Chu et al,6 2003	55 F	Mild Cushing syndrome	Cortisol, ACTH*	2.5
Ma et al,7 2007	41 F	Cushing syndrome, intraoperative HTN	Cortisol, ACTH*	4
Lee et al,8 2008	25 F	Cushing syndrome, gestational diabetes, HTN	Cortisol, catecholamines	3.2
Kimura et al,9 2009	54 F	HTN, diabetes	Cortisol, catecholamines	4.9
Alexandraki et al,10 2009	66 F	Subclinical Cushing syndrome	Cortisol, ACTH*	4.2
Singh et al,11 2010	48 F	Abdominal distention, pedal oedema	Catecholamines	8
Lau et al,12 2011	64 F	HTN	Catecholamines	3.6
Donatini et al,13 2013	53 M	Right flank pain	Catecholamines	5.5
Turk et al,14 2012†	78 F	Hypertensive urgency	Catecholamines	10
Michalopoulos et al,15 2013†	63 M	Right upper quadrant palpable mass	Cortisol, ACTH*	8
Total number of cases: 17	Median age 53.5 years (range 25–78) Females 82% (14/17) Males 18% (3/17)	Cushing syndrome 47% (8/17) Intraop HTN 18% (3/17) HTN 47% (8/17)	Cortisol 71% (12/17) Aldosterone 12% (2/17) Catecholamines 59% (10/17) ACTH* 88% (7/8)	Median size 4.5 cm (range: 2.5–10)

*ACTH was detectable (non-suppressed) in the setting of hypercortisolaemia.

†Mixed corticomedullary carcinoma (MCMC).

HTN, hypertension; Intraop, intraoperative.