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Virulence of A. fumigatus wild-type strain ATCC 46645, as well as ΔgpaB (A) and ΔpkaC1 (B) deletion strains, in mice. The members of groups of 10 BALB/c mice were each infected with 5 × 103 or 104A. fumigatus conidia, as indicated, by nasal inhalation. Survival was monitored for 15 days.