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. 2016 Dec 21;6:39420. doi: 10.1038/srep39420

Figure 7. Matrix protein of Tha virus modulates the transcription of TNF in vivo.

Figure 7

Relative quantification of TNF mRNA expression was performed in the brain of mice infected with Tha and Th4M viruses. Four six-weeks-old BALB/c were infected in intramuscular injection of 1000 FFU and monitored over 21 days. The mice were sacrified upon the apparition of late infection symptoms (humane endpoint) and RNA were extracted from the brain. The expression of the TNF mRNA was studied by RT-qPCR analysis. The levels of gene expression were normalized according to the level of GAPDH reporter gene in non-infected mice. Significant results (p < 0.05) compared to uninfected mice (#) and Tha (##) infected mice are annoted.