Figure 3. The relative abundances of acne- and health-associated metagenomic elements in acne and healthy individuals.

(A) The relative abundances of 62 P. acnes OGUs, including 25 acne- and 37 health-associated OGUs, and three organisms associated with healthy skin, P. acnes, P. granulosum, and P. acnes phage, were plotted for each individual to illustrate the importance of a balance between these metagenomic elements in health and acne. Each column represents an individual, and each row represents an OGU or an organism. The top ten ribotype composition and acne severity score (acne patients only) of each individual are also shown. (B) The prediction score of each individual based on the relative abundances of the 45 metagenomic elements is shown, where red indicates acne and green indicates healthy skin. The classification of the clinical states had an overall accuracy of 85%.