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. 2016 Dec 21;6:39520. doi: 10.1038/srep39520

Figure 1. Human infiltrating macrophages express M2 macrophage markers in HCV-infected humanized mice livers.

Figure 1

Representative livers of NTP-HCV (Non-transplanted mice inoculated with HCV), Hep/HSC TP - Mock or HCV (humanized mice with human hepatocytes and immune cells inoculated with Mock or HCV+ serum), Hep TP-HCV (humanized mice transplanted with adult hepatocytes inoculated with HCV) were stained for human pan-macrophage marker - hCD68 (A) and human M2 (hCD206, hCD163) and M1 (hiNOS, hCD86) markers (B). Additionally, liver RNA was isolated from Hep/HSC TP – Mock (N = 3) or HCV (N = 10) and qPCR analysis was performed to examine human (C) M1 macrophage polarization markers (hCD80, hCD86) and (D) M2 macrophage polarization markers (hARG1, hCD163).