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. 2016 Dec 21;6:39549. doi: 10.1038/srep39549

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Copyright © 2016, The Author(s)

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(a) Secondary structure of pseudoknot SF206 and mutants. The slippery sequence (G GGA AAC) is indicated by a vertical black line. The DNA strands (highlighted in dark gray) are complementary to the mRNA (highlighted in light gray) forming the handles A and B for the pulling experiments. (b) Experimental setup of single-molecule force spectroscopy using Minitweezers. The NMR structure¹⁸ is shown with the same color coding as panel a. The drawing is not to scale. (c) Structures of the three consecutive minor-groove base triples A28∙C6-G14 (cyan), U27∙C5-G15 (green), and A26∙G4-C16 (magenta) found in SF206.