Table 1.
Telomerase activation and E6-AP binding of E6 proteins
| HPV 16E6 protein | TRAP activity | E6-AP binding | p53 degradation | References |
|---|---|---|---|---|
| 16E6 wt | + | + | + | Klingelhutz et al. 1996; Liu et al. 1999 |
| 16E6 F2V | + | + | − | Liu et al. 1999; data not shown |
| 16E6 8S/9A/10T | + | + | − | Foster et al. 1994; Klingelhutz et al. 1996; Gewin and Galloway 2001 |
| 16E6Δ9-13 | − | − | − | Foster et al. 1994; Gewin and Galloway 2001 |
| 16E6 L50G | − | − | − | Zimmermann et al. 1999; data not shown |
| 16E6 Y54H | +a | + | − | Liu et al. 1999 |
| 16E6 Δ118-122b | −/+a | −/+ | −/+ | Foster et al. 1994; Dalal et al. 1996; Kiyono et al. 1998 |
| 16E6 Δ123-127 | − | − | − | Foster et al. 1994; Klingelhutz et al. 1996; Liu et al. 1999 |
| 16E6 Δ146-151 | + | NT | + | Foster et al. 1994; Klingelhutz et al. 1996; Kiyono et al. 1998 |
(NT) Not tested.
a
TRAP activity is inferred by the ability of these mutants to immmortalize mammary epithelial cells (MECs).
b
16E6 Δ118-122 appears to have low-level activity in all of these functions.