Table 2. In vitro growth inhibitory activity (expressed as IC50) of the human and chimeric AMA1-specific antibodies against P. falciparum strains 3D7A, HB3 and FCR3.
Parasite strain | 3D7A | HB3 | FCR3 |
---|---|---|---|
Antibody | |||
IC50 (95% Confidence Interval) | |||
humAbAMA1 (N.b.) | 35 (33–37) μg/ml | 126 (112–141) μg/ml | 196 (159–239) μg/ml |
humAbAMA1 (HEK293-6E) | 35 (34–37) μg/ml | ND | ND |
4G2 (N.b.) | 105 (99–111) μg/ml | 396 (362–433) μg/ml | 817 (674–990) μg/ml |
1F9 (N.b.) | 292 (250–342) μg/ml | >1750 μg/ml | 1438 (1233–1676) μg/ml |
ND: Not determined; N.b.: Nicotiana benthamiana.