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. 2016 Dec 24;6(4):719–728. doi: 10.5500/wjt.v6.i4.719

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©The Author(s) 2016. Published by Baishideng Publishing Group Inc. All rights reserved.

This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial.

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Histopatholgy of intestinal allograft. A and B: No rejection: normal mucosal architecture of small bowel biopsy after transplantation. No staining for C4d is seen in the capillaries of the lamina propria; C and D: Acute cellular rejection (ACR): There is mononuclear infiltration, crypt epithelial injury, and apoptotic bodies (arrows) in the lamina propria. Weak and focal staining for C4d (arrows) is sometimes present in a patient with ACR; E and F: Acute antibody-mediated rejection (ABMR): There is prominent hemorrhage and congestion with scattered fibrin thrombin in the lamina propria. Widespread and bright staining for C4d is present in the capillaries of the lamina propria. Magnifications: × 200 in A, E and F; × 400 in B, C and D. A, C, E: H and E; B, D, F: C4d.