Table 2.
Characteristics of 18 patients with diagnosis of acute antibody-medicated rejection
Case | Tx type | POD (d) |
XM |
DSA at time of Tx and/or rejection | De novo DSA | Vascular alterations | C4d | #ACR≤ 360 d | |
T-cell | B-cell | ||||||||
1 | MV + K | 4 | 1:32 | 1:16 | A1, A25, B8, B18 | DR51 | ++ | Focal | 0 |
2 | SB | 5 | 1:256 | 1:512 | B7, B44, BW4, DQ1, DR10 | DR15, DR51 | +++ | Diffuse | 2 |
3 | SB | 5 | 1:2 | 1:2 | B60 | DR16 | ++ | Diffuse | 3 |
41 | SB | 6 | 1:8 | 1:8 | B35, B60 | A31, DQ7, DR11 | +++ | Diffuse | 0 |
109 | A24, B604 | DR14, DR52 | ++ | Diffuse | |||||
5 | SB | 7 | Neg | 1:1 | A3, B18, DR17 | None | ++ | Diffuse | 0 |
6 | MV | 7 | Neg | 1:8 | A26, B70, DR52 | None | ++ | Diffuse | 1 |
7 | MMV | 9 | 1:32 | 1:8 | A2 | None | +++ | Diffuse | 4 |
8 | SB | 10 | Neg | Neg | DR52 | None | ++ | Diffuse | 1 |
9 | MMV | 10 | 1:2 | 1:2 | B13, BW4, DR7, DR53 | DQ1 | ++ | Diffuse | 2 |
101 | SB + K | 11 | Neg | 1:4 | A32, B8 | A1, DR17 | ++ | Diffuse | 4 |
52 | A32, DQ44 | ++ | Diffuse | ||||||
11 | SB + P | 14 | Neg | 1:4 | A3, B64 | DQ7 | ++ | Diffuse | 0 |
121 | SB | 15 | Neg | Neg | A2, B50 | DQ8, DR53, DR4 | + | Diffuse | 5 |
112 | B7, B504 | + | Focal | ||||||
13 | SB | 41 | 1:256 | 1:8 | A3, BW4, B53 | DR18 | +++ | Diffuse | 2 |
14 | MMV | 84 | 1:4 | 1:1 | A25, B14, B18 | None | ++ | Diffuse | 1 |
15 | SB | 140 | Neg | Neg | A24 | A28, B78, A30, DQ7, 9 | + | Diffuse | 1 |
16 | SB | 162 | 1:2 | 1:2 | A24, B444 | DQ1, CW5 | ++ | Diffuse | 2 |
172 | SB | 4 | Neg | Neg | A28, B78, A30, DQ7, 9 | B44, B58, DR4 | +++ | Diffuse | 2 |
183 | MMV | 18 | 1:1 | 1:8 | A11, B7, DR12, DR17, DQ2 | None | ++ | Diffuse | 1 |
Type of transplant: SB: An isolated small bowel; MMV: A modified multivisceral graft; MV: A full multivisceral graft; P: Pancreas; K: Kidney.
Patients with repeat ABMR;
Patient with a history of ABMR after prior transplant;
Patient with prior transplant;
DSA detected at time of rejection. POD: ABMR days post-transplant; XM: Cross-match; DSA: Donor-specific antibody; ACR: Acute cellular rejection.