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. 2016 Jul 19;44(20):9624–9637. doi: 10.1093/nar/gkw633

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© The Author(s) 2016. Published by Oxford University Press on behalf of Nucleic Acids Research.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by-nc/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact journals.permissions@oup.com

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Figure 5. — RAG1^hi clusters represent two modes of interaction mediated by different RAG1 and RAG2 domains. (A) Schematic representation of the expected RAG1 targeting interactions in wt, cR1 and R2ΔC genotypes. (B) Comparison of RAG1 levels in Cluster 1 (H3K4me3-driven) and Cluster 2 (H3K27Ac-driven) in WT, cR1 and R2ΔC genotypes. In both WT and cR1, RAG1 levels are higher in Cluster 1 than Cluster 2, but the differences are much greater in cR1 (t-test; P < 1e-5 and P < 1e-35, respectively). In R2ΔC, RAG1 levels are higher in cluster 2 (P < 1e-9). (C) Correlation between the levels of RAG1 in the indicated genotypes and H3K4me3, H3K27Ac or DNaseI-HS. Spearman correlation coefficients are indicated on each plot in the bottom right corner and the MSE is indicated by background color.