FIG. 2.
(a) Frequency of arthritis in mice inoculated with 3 × 106 to 4 × 106 CFU of S. aureus 8325-4 (rsbU mutant), SH1000 (rsbU+), or MJH502 (sigB mutant) (derived from SH1000). Data from two experiments are pooled (n = 20). Statistical comparison between SH1000 and 8325-4 or MJH502 was done by the chi-square test with Yates correction. (b) Severity of arthritis in mice inoculated with 3 × 106 to 4 × 106 CFU of S. aureus 8325-4 (rsbU mutant), SH1000 (rsbU+), or MJH502 (sigB mutant) (derived from SH1000). Data from two experiments are pooled (n = 20). 1, mild swelling and/or erythema; 2, moderate swelling and erythema; 3, marked swelling and erythema. The scores from all limbs for each animal were added. Data are medians (bold line) and IQRs for each group of mice. Statistical comparison between SH1000 and 8325-4 or MJH502 was done by using the Mann-Whitney U test.
