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(a) Micrograph showing the knee joint from a NMRI mouse 14 days after inoculation with 4 × 106 CFU of strain SH1000, displaying severe inflammation of synovial tissue and bone and cartilage erosion. (b) Micrograph showing an apparently intact knee joint from a mouse inoculated with the same dose of MJH502 (sigB mutant). JC, joint cavity; C, cartilage; S, synovial tissue; E, erosion of bone and/or cartilage; P, pannus formation. Bar, 200 μm. Hematoxylin and eosin staining was used.
