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. 2016 Sep 28;44(20):9519–9529. doi: 10.1093/nar/gkw867

Figure 2.

Figure 2.

ASO-MALAT1 and RNA content in tissues of P7 mice dosed with ASO-MALAT1 by amniotic cavity injection at E13-13.5. (A) ASO-MALAT1 concentration in P7 mouse tissues measured by HPLC coupled with tandem mass spectrometry detection (mean ± s.e.m., n = 5 except brain and spinal cord, n = 4). (B) The relative quantity (RQ) of MALAT1 RNA normalized to β-actin RNA in the indicated tissues from P7 mice whose amniotic cavities were injected with 80 μg of ASO-MALAT1 (n = 6; except liver and inner ear, n = 5) or ASO-C (n = 3) at E13-13.5. The dotted line represents the normalized control value of 1. Error bars represent s.e.m, **P < 0.01, ***P < 0.001, ****P < 0.0001, One-sample t-test.