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. 2016 Dec 21;22:34. doi: 10.1186/s40409-016-0091-6

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© The Author(s). 2016

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 2 — Partial antagonism induced by intracerebroventricular administration of a naloxone, b clocinnamox, c naltrindole or d AM251 in the central antinociception induced by PnPP-19. Naloxone (Nal; 2.5 and 5 μg), clocinnamox (Clo; 2 and 4 μg), naltrindole (NTD; 6 and 12 μg) or AM251 (2 and 4 μg) was administered 1 min prior to PnPP-19 injection (1 μg). These antagonists did not significantly modify the nociceptive threshold in the control group. Each line represents the mean ± SEM for four mice per group. *Significant difference compared to the control group (ANOVA + Bonferroni’s test). Sal: saline (0.5% of Evans Blue); Veh: vehicle (20% DMSO in saline 0.5% of Evans Blue)