Table 1.
Functional Connectivity Cluster Details
| Rest | Cyclic Pain | Tonic Pain | ||||
|---|---|---|---|---|---|---|
| Brain region | Z-Max | x, y, z | Z-Max | x, y, z | Z-Max | x, y, z |
| aIns Seed | ||||||
| Right Insula | 6.15 | 34, 20, 0 | 5.11 | 34, 20, 2 | 4.27 | 48, 6, −2 |
| ACC (BA 24) | 4.60 | 2, 18, 40 | 3.44 | −2, 12, 42 | 3.98 | 0, 20, 20 |
| Left SI | — | — | 2.54 | −34, −32, 62 | — | — |
| Left SII | 3.45 | −62, −32, 18 | 3.92 | −60, −26, 22 | — | — |
| BA 17 (L Cuneus) | −3.74 | −32, −88, 10 | −2.94 | −24, −96, 14 | — | — |
| BA 17 (R Cuneus) | — | — | — | — | — | — |
| sgACC | — | — | −4.34 | −10, 32, −14 | — | — |
| Right SII | 3.01 | 60, −20, 16 | 3.55 | 68, −28, 12 | — | — |
| BA 6 | — | — | — | — | 3.46 | 4, 16, 56 |
| Left Crus I | — | — | — | — | −3.01 | −14, −82, −30 |
| BA 9 | — | — | — | — | 4.37 | −28, 50, 22 |
| Precuneus | — | — | −3.94 | −4, −62, 24 | — | — |
| PCC | — | — | −3.44 | 6, −50, 34 | — | — |
| pIns Seed | ||||||
| Right Insula | 4.02 | 40, −4, 4 | 5.00 | 36, 2, 10 | 3.38 | 34, 0, 8 |
| ACC (BA 24) | 3.03 | −6, 8, 40 | 4.13 | 8, 20, 42 | 3.65 | 0, 8, 30 |
| Left SI | 3.87 | −48, −34, 48 | 4.88 | −60, −28, 42 | 3.87 | −44, −32, 40 |
| Left SII | 5.19 | −62, −10, 22 | 4.54 | −66, −26, 24 | 3.38 | −58, −32, 20 |
| Right SI | 3.35 | 36, −30, 54 | 4.34 | 56, −20, 52 | 3.65 | 62, −36, 38 |
| Right SII | 4.45 | 52, −10, 26 | 5.86 | 62, −26, 18 | 4.05 | 48, −26, 10 |
| Lingual Gyrus | −3.75 | −30, −56, −2 | — | — | — | — |
| BA 8/BA 6 | −3.10 | 26, 28, 50 | −4.3 | 26, 26, 46 | — | — |
| Left Crus I | −4.04 | −24, −70, −34 | — | — | — | — |
| Precuneus | −3.89 | 8, −68, 32 | −3.72 | 4, −64, 32 | −3.79 | −6, −60, 32 |
| PCC | −2.72 | 4, −40, 28 | −4.40 | 4, −48, 32 | −3.97 | 10, −50, 24 |
| ACC Seed | ||||||
| Left Insula | 4.69 | −46, −26, 6 | 4.68 | −38, 6, −2 | — | — |
| Right SII | 5.82 | 52, −36, 20 | 5.52 | 60, −26, 20 | 4.91 | 58, −34, 20 |
| Vermis | −5.23 | 0, −44, −38 | −3.44 | 6, −40, −38 | — | — |
| Left SII | 4.18 | −64, −8, 14 | 4.39 | −48, −32, 10 | 4.30 | −58, −32, 18 |
| R Cuneus | −3.23 | 32, −76, 40 | −4.34 | 44, −66, 30 | — | — |
| L Cuneus | −3.11 | −34, −80, 30 | −3.05 | −50, −72, 30 | — | — |
| Precuneus | — | — | −3.13 | −4, −72, 32 | — | — |
| PCC | — | — | −2.99 | −2, −52, 18 | — | — |
| Right Insula | 4.51 | 62, −10, 2 | 4.96 | 38, 0, 6 | 3.64 | 44, 2, 6 |
Local maximum Z-score (Max Z) and corresponding coordinates in the MNI standard space brain for connectivity clusters in the Rest, Cyclic Pain, and Tonic Pain datasets analyzed with seed regions in the left anterior and posterior insular cortices and the ACC24. Negative Z-scores reflect anticorrelation (further explained in the text). sgACC refers to the subgenual portion of the ACC in BA 32.
ACC, anterior cingulate cortex; aIns, anterior insula; BA, Brodmann area; MNI, Montreal Neurological Institute; PCC, posterior cingulate cortex; pIns, posterior insula; SI, primary somatosensory cortex; SII, secondary somatosensory cortex.