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. 2004 Oct;72(10):5722–5732. doi: 10.1128/IAI.72.10.5722-5732.2004

FIG. 3.

FIG. 3.

Hematoxylin and eosin-stained cross sections of lung tissues from knockout and wild-type mice. (A) Tissue from CXCR2-KO mouse 21 days after inoculation with Pneumocystis (magnification, ×200). Note the perivascular cuffing of inflammatory cells and Pneumocystis. (B) Tissue from wild-type BALB/c mouse 21 days after inoculation with Pneumocystis, showing more-diffuse inflammation and Pneumocystis growth (magnification, ×200). (C) Tissue from uninfected BALB/c mouse (magnification, ×200). (D) Tissue from gp91phox-KO mouse 35 days after inoculation with Pneumocystis (magnification, ×200). (E) Tissue from wild-type C57BL/6 mouse 35 days after inoculation with Pneumocystis (magnification, ×200). (F) Tissue from phox/iNOS-KO mouse 35 days postinoculation, showing tight clusters of Pneumocystis pushing into airways (magnification, ×200). (G) Tissue from CXCR2-KO mouse 35 days after inoculation with Pneumocystis (magnification, ×600). Pneumocystis, macrophages, and lymphocytes are present in the alveolar space, while neutrophils are virtually absent from the alveoli but present in pulmonary blood vessels and the interstitial space. (H) Tissue from C57BL/6 wild-type mouse 35 days after inoculation with Pneumocystis (magnification, ×600), showing mixed alveolar infiltrate of neutrophils, macrophages, and lymphocytes. (I) Tissue from phox/iNOS-KO mouse 35 days after inoculation with Pneumocystis (magnification, ×600), showing large numbers of neutrophils, as well as macrophages and lymphocytes, in the alveolar space.