Figure 1.
Genetic dependencies of BPDCN identified by shRNA screen. A) shRNA screen hits: for each gene, the average -Log2 FC depletion of toxic shRNAs is shown. B) The shRNAs toxic to Cal-1 cells were ranked based on differential depletion with respect to the average of 3 control cell lines: CCRF-CEM, Jurkat and SKM-1. The top 20 shRNAs specifically toxic to BPDCN Cal-1 are shown. See also Figure S1 and Table S1.