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. Author manuscript; available in PMC: 2017 Nov 14.
Published in final edited form as: Cancer Cell. 2016 Nov 14;30(5):764–778. doi: 10.1016/j.ccell.2016.10.002

Figure 4.

Figure 4

TCF4 expression facilitates BPDCN diagnosis. A) The results of the unsupervised hierarchical clustering performed based on the TCF4 IHC scoring are shown. See Table S4. B) Representative TCF4 and hematoxylin and eosin (H&E) stains are shown at 40X magnification for 2 BPDCN cases and 1 AML case. C) Heat-map view of RNA-Seq expression levels of TCF4-activated genes in the indicated samples, grouped by unsupervised hierarchical clustering. Red indicates genes characteristically expressed in pDCs (DC-1 or DC-4 signatures) whereas blue indicates genes associated with cell proliferation (Prolif-5 signature) (Shaffer et al., 2006). D) The FFPE RNA-Seq digital gene expression values are shown for TCF4 and the indicated TCF4 targets. The black line indicates the mean. See also Figure S4 and Table S4.