TABLE 1.
DTH responses (skin test) in vaccinated guinea pigs
| Vaccine group | DTH response (mm) (mean ± SEM)a
|
||
|---|---|---|---|
| BCG CF | Ag85B | dESAT-6 | |
| BCG | 17.4 ± 1.2 | ND | ND |
| Ag85B-ESAT-6 fusion | ND | 14.3 ± 1.4 | 21.0 ± 2.8 |
| Ag85B | ND | 19.1 ± 1.4 | ND |
| ESAT-6 | ND | ND | 12.8 ± 1.1 |
| Ag85B+ESAT-6 cocktail | ND | 15.1 ± 1.2 | 17.7 ± 1.1 |
a
DTH responses were read 24 h after vaccination with 2.5 μg of BCG culture filtrate (CF), Ag85B, or dESAT-6. The values given are the mean diameters of the lesions for four guinea pigs. Responses larger than 5 mm were regarded as positive. Responses to phosphate-buffered saline were less than 5 mm. ND, not done (only antigens included in the vaccine were tested for DTH reactivity).