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. 2016 Dec 21;7:632. doi: 10.3389/fphys.2016.00632

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Copyright © 2016 Siddiqui, Tikunova, Walton, Liu, Meyer, de Tombe, Neilson, Kekenes-Huskey, Salhi, Janssen, Biesiadecki and Davis.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Application of a four state model. Panels (A,B) in black show the apparent Ca²⁺ sensitivity and dissociation rates from the Tn complex as previously published (Davis et al., 2007). Panels (C,D) in black show the apparent Ca²⁺ sensitivity and dissociation rates from the reconstituted thin filament as previously published (Davis et al., 2007). Panel (E) in black shows the rates of Ca²⁺ association to the reconstituted thin filaments as previously published (Liu et al., 2012b). Panel (F) (noisy colored curves) shows the response of the thin filaments to artificial Ca²⁺ transients as previously published (Liu et al., 2012b). For Panel (A–E), the smooth red curves show the simulated output of the four state model. For Panel (F), all the smooth curves represent the simulated output of the four state model.