TABLE 4.
Statistical significance of differences in peak parasitemia and survival outcome of mice immunized with various recombinant MSP4/5 proteins and challenged with P. y. yoelii YM
| Immunizing MSP4/5 antigen | Parameter | Significancec
|
||||
|---|---|---|---|---|---|---|
| Control mice | P. y. yoelii YM MSP4/5 | P. y. killicki 193L MSP4/5 | P. y. nigeriensis N67 MSP4/5 | P. berghei ANKA MSP4/5 | ||
| P. y. yoelii YM | Peak parasitemiaa | P < 0.0001 (SD) | ||||
| Survivalb | P < 0.0001 (SD) | |||||
| P. y. killicki 193L | Peak parasitemia | P < 0.0001 (SD) | P = 0.0328 (SD) | |||
| Survival | P < 0.0001 (SD) | P = 1.5152 (NSD) | ||||
| P. y. nigeriensis N67 | Peak parasitemia | P < 0.0001 (SD) | P = 0.1093 (NSD) | P = 0.8854 (NSD) | ||
| Survival | P < 0.0001 (SD) | (NSD) | ||||
| P. berghei ANKA | Peak parasitemia | P = 0.0001 (SD) | P < 0.0001 (SD) | P = 0.0013 (SD) | P = 0.0004 (SD) | |
| Survival | P < 0.0001 (SD) | P < 0.0479 (SD) | ||||
| Reduced and alkylated P. berghei ANKA | Peak parasitemia | P = 0.9372 (NSD) | P = 0.0022 (SD) | |||
| Survival | (NSD) | P = 0.0022 (SD) | ||||
| P. c. adami DS | Peak parasitemia | P = 0.4522 (NSD) | P = 0.0003 (SD) | P = 0.0046 (SD) | P = 0.0017 (SD) | P = 0.1547 (NSD) |
| Survival | P = 0.6581 (NSD) | P < 0.0001 (SD) | P = 0.0044 (SD) | |||
a
Statistical analysis of peak parasitemias was performed with the Mann-Whitney U test.
b
Statistical analysis of survival outcome was performed with Fisher's exact test.
c
NSD, no significant difference; SD, significant difference (P < 0.05).