FIG. 1.
Differential susceptibility of A/J and C57BL/6J mice to C. albicans infection. (A) Survival of A/J and C57BL/6J mice after intravenous infection with C. albicans. Twelve A/J and 25 C57BL/6J (B6) mice were injected intravenously with a C. albicans suspension and subsequently monitored for clinical signs as described in Materials and Methods. The figure shows the percent survival at various intervals postinfection. The figure presents data from one of three independent experiments. All three experiments gave comparable results. (B) Tissue distribution of C. albicans in A/J and C57BL/6J mice 24 h postinfection. Six mice each of the two strains were injected intravenously with 3 × 105 Candida blastospores, and tissue fungal load was determined 24 h postinfection as described in Materials and Methods. Results represent a compilation of two independent experiments. The standard error of the mean is indicated for each sample. Asterisks indicate statistically significant differences (P = 0.001).