Fig. 1.

Impact of systemic TNF-α on working memory in NBH and ME7 animals. Percentage T-maze alternation post-systemic TNF-α (50 μg/kg) or saline administration in ME7 or NBH animals, 16 weeks post-inoculation. Data were analysed using a two-way ANOVA followed by a Bonferroni multiple comparison test comparing individual time-points. Three-way ANOVA was used to test overall significance. Statistically significant differences are denoted by ^∗(P < 0.05), ^∗∗(P < 0.01), ^∗∗∗(P < 0.001). All data are represented as the mean ± SEM, n = 9–15 for all groups.