Fig. 2.

Central and systemic inflammatory markers post-systemic TNF-α. Hippocampal (a-c) and hypothalamic (d-f) transcripts, and plasma (g-h) and hippocampal (i) protein at 2 and 4 h post TNF-α (50 μg/kg) i.p in ME7 or NBH animals, 16 weeks post-inoculation. Data were analysed using a two-way ANOVA followed by Bonferroni post-hoc test. Statistically significant differences between NBH and ME7 groups are denoted by ^∗(P < 0.05), ^∗∗(P < 0.01), ^∗∗∗(P < 0.001). # denotes a disease × treatment interaction. All data are represented as the mean ± SEM, n = 3–5 for all groups.