Table 2.
Weight-loss programs: summary results (difference in mean weight loss [kg]) and GRADE assessment of the direct and indirect analyses and NMAs
| Comparison (active vs. control) | Mean difference (95% CI) |
Quality of evidence (GRADE) |
||||
|---|---|---|---|---|---|---|
| Direct | Indirect | Network | Direct | Indirect | Network | |
| LEARN vs. No diet | 3.67 (−3.88, 11.21) | 3.63 (0.36, 6.91) | 5.16 (2.68, 7.63) | Low | Low | Low |
| Moderate vs. No diet | 4.84 (2.82, 6.86) | 4.69 (1.73, 7.75) | 5.70 (4.14, 7.35) | Low | Low | Moderate |
| Low Carb vs. No diet | 9.34 (7.31, 11.37) | 5.16 (2.25, 8.18) | 7.25 (5.33, 9.25) | Low | Moderate | Moderate |
| Low fat vs. No diet | 5.97 (2.01, 9.92) | 6.15 (2.96, 9.40) | 7.27 (5.26, 9.34) | Moderate | Moderate | Moderate |
| Moderate vs. LEARN | 0.21 (−4.64, 5.05) | 0.94 (−1.74, 3.66) | 0.55 (−1.71, 2.87) | Low | Low | Low |
| Low Carb vs. LEARN | 1.23 (−1.22, 3.67) | 2.48 (−0.19, 5.19) | 2.10 (−0.20, 4.47) | Low | Low | Low |
| Low fat vs. LEARN | 4.00 (−0.21, 8.21) | 2.64 (−0.02, 5.33) | 2.12 (−0.33, 4.59) | Low | Low | Low |
| Low Carb vs. Moderate | 1.07 (0.16, 1.97) | 2.05 (−0.92, 4.96) | 1.55 (0.13, 2.95) | Moderate | Low | Moderate |
| Low fat vs. Moderate | 1.84 (0.96, 2.72) | 1.38 (−0.75, 3.51) | 1.56 (−0.17, 3.30) | Moderate | Low | Moderate |
| Low fat vs. Low Carb | 0.33 (−0.86, 1.52) | 0.39 (−1.92, 2.70) | 0.02 (−1.78, 1.79) | Low | Moderate | Moderate |
Abbreviations: GRADE, Grading of Recommendations Assessment, Development and Evaluation; NMAs, network meta-analyses; CI, confidence interval.