Fig. 6.

Distribution of MG160 in the GA of AT8 − and AT8 + human CA1 and neocortical pyramidal neurons in a non-demented control case

Pairs of confocal stack projection images taken from CA1 (A–C) and areas 21 (D–F) and 38 (G–I) of the temporal neocortex from sections double-immunostained for MG160/AT8 showing the distribution of MG160 in the GA of AT8 −, and AT8 + (type I and type II) pyramidal neurons from a human in a non-demented control case. Scale bar in I indicates 24 μm in A–C, 14 μm in D–F and 22,65 in G–I. Histograms show surface area (J) and volume (K) values (mean ± SE) of MG160-ir GA elements, in AT8 − neurons (area 38 n = 397; area 21 n = 133; CA1 n = 185) and AT8 + neurons (patterns I and II; area 38, n = 49; area 21, n = 12; CA1, n = 47). Note that both surface area and volume values were significantly reduced in type II AT8 + neurons, compared to AT8 − neurons (Friedman test, *p ≤ 0.01; **p ≤ 0.001).