TABLE 3.
Invasion of normal cells (WT), cells lacking GPA [En(a−)], and wild-type cells age- and storage-matched to En(a−) cells (FrC) by P. falciparum field isolates
| Isolate | % Parasitemia ± SD in:
|
||
|---|---|---|---|
| WT | FrC | En(a−) | |
| 3D7 | 2.3 ± 0.30a | 1.5 ± 0.05 | 0.8 ± 0 |
| ALR | 1.4 ± 0.10 | 1.2 ± 0.08 | 0.05 ± 0.01b |
| JSL | 1.8 ± 0 | 1.6 ± 0.16 | 0.9 ± 0.06 |
| GVM | 1.4 ± 0.04 | 1.0 ± 0.20 | 0.9 ± 0.12 |
| FFS | 0.8 ± 0.10 | 0.8 ± 0.10 | 0.15 ± 0.04b |
| 04Q | 1.3 ± 0.35 | 1.5 ± 0.23 | 0.9 ± 0.26 |
| BHZ | 1 ± 0.25 | 0.9 ± 0.06 | 0.7 ± 0.13 |
| PSS1 | 1.3 ± 0.16 | 1.2 ± 0.05 | 1.2 ± 0.03 |
a
Percent parasitemia (percentage of infected cells) was calculated using the average number from triplicate wells, of infected erythrocytes.
b
Results for the two strains that are postulated to use GPA as the primary receptor are given in bold.