TABLE 4.
Lack of association between sequence polymorphism in EBA-140 and EBA-181 and invasion phenotypes
| Invasion profile | Isolate | Amino acid (codon) at EBA-140 region IIa position:
|
Amino acid (codon) at EBA-181 region IIb position:
|
|||||||
|---|---|---|---|---|---|---|---|---|---|---|
| 185 | 239 | 261 | 285 | 359 | 363 | 414 | 443 | 637 | ||
| NsTsCr | 3D7 | I (ATT) | N (AAT) | K (AAG) | K (AAA) | R (AGG) | V (GTT) | N (AAT) | K (AAA) | N (AAT) |
| ALR | V (GTT) | S (AGT) | T (ACG) | K (AAA) | R (AGG) | V (GTT) | N (AAT) | K (AAA) | N (AAT) | |
| JSL | V (GTT) | S (AGT) | T (ACG) | K (AAA) | R (AGG) | V (GTT) | N (AAT) | K (AAA) | K (AAA) | |
| GVM | V (GTT) | S (AGT) | T (ACG) | K (AAA) | K (AAG) | V (GTT) | I (ATT) | Q (CAA) | N (AAT) | |
| PSS1 | I (ATT) | N (AAT) | K (AAG) | K (AAA) | K (AAG) | V (GTT) | I (ATT) | Q (CAA) | N (AAT) | |
| BHZ | V (GTT) | S (AGT) | T (ACG) | K (AAA) | R (AGG) | V (GTT) | N (AAT) | Q (CAA) | N (AAT) | |
| O4Q | V (GTT) | S (AGT) | T (ACG) | K (AAA) | R (AGG) | V (GTT) | N (AAT) | Q (CAA) | N (AAT) | |
| FFS | V (GTT) | S (AGT) | T (ACG) | K (AAA) | R (AGG) | V (GTT) | N (AAT) | Q (CAA) | N (AAT) | |
| NsTrCr | Dd2 | V (GTT) | S (AGT) | T (ACG) | K (AAA) | R (AGG) | V (GTT) | I (ATT) | Q (CAA) | N (AAT) |
| GOS | V (GTT) | S (AGT) | T (ACG) | K (AAA) | R (AGG) | V (GTT) | I (ATT) | Q (CAA) | N (AAT) | |
| NS | V (GTT) | S (AGT) | T (ACG) | K (AAA) | R (AGG) | V (GTT) | I (ATT) | Q (CAA) | N (AAT) | |
| LANA | V (GTT) | S (AGT) | T (ACG) | K (AAA) | R (AGG) | V (GTT) | I (ATT) | Q (CAA) | N (AAT) | |
| IPN | V (GTT) | S (AGT) | T (ACG) | K (AAA) | R (AGG) | V (GTT) | I (ATT) | Q (CAA) | N (AAT) | |
| 35Q | I (ATT) | N (AAT) | K (AAG) | K (AAA) | R (AGG) | V (GTT) | N (AAT) | K (AAA) | N (AAT) | |
| NrTsCr | 7G8 | V (GTT) | S (AGT) | T (ACG) | K (AAA) | R (AGG) | V (GTT) | N (AAT) | Q (CAA) | N (AAT) |
| 21Q | V (GTT) | S (AGT) | T (ACG) | K (AAA) | R (AGG) | V (GTT) | N (AAT) | K (AAA) | N (AAT) | |
| NsTsCs | RPN | I (ATT) | N (AAT) | K (AAG) | K (AAA) | R (AGG) | V (GTT) | N (AAT) | K (AAA) | N (AAT) |
a
The(INKK(variant(is(bolded(to(distinguish(it(from(the(VSTK(variant.
b
The(RVIQN(variant(is(italicized,(the(RVNKN(variant(is(bolded,(the(RVNKK(variant(is(underlined,(and(the(KVIQN(variant(is(bolded(and(italicized(to(distinguish them(from(the(RVNQN(variant.