Figure 2.

Effect of paclitaxel treatment on mitosis and survival of apoptosis-prone and -reluctant cell lines. (A) Duration of mitotic arrest of the 4 cell lines and their behavior on mitotic exit after treatment with 3 and 10 nM paclitaxel. Horizontal lines represent mitotic arrest of individual cells sorted by the type of behavior on mitotic exit and the time of arrest onset. Black, (apparently) symmetric division; red, MOMP during arrest; orange, exit with no division (mitotic slippage); green, asymmetric division; blue, ternary division; purple, miscellaneous. (B) Cell survival immediately after paclitaxel treatment for 48 h measured using the WST assay (see Materials and Methods). (C) Colony-forming ability after paclitaxel treatment for 48 h. The results are shown as mean ± SEM (n = 3).