Table 1.
Univariate and multivariate analysis of risk factors associated with relapse-free survival.
| TCGA data set | ||||||
|---|---|---|---|---|---|---|
| Univariate analysis |
Multivariate analysis |
Multivariate analysis in ER-positive |
||||
| Variable | HRb (95% CIc±) | p-value | HRb (95% CIc±) | p-value | HRb (95% CIc±) | p-value |
| AIRE positivity | 0.59 (0.52) | 0.0456 | 0.46 (0.58) | 0.0092 | 0.39 (0.77) | 0.0181 |
| Tumor size >2 cm | 1.98 (0.59) | 0.0243 | 1.54 (1.03) | 0.4145 | 4.25 (1.99) | 0.1548 |
| Tumor stage II,III,IV | 3.57 (0.91) | 0.0062 | 1.45 (1.42) | 0.6119 | 0.44 (2.28) | 0.4842 |
| ER positivity | 0.61 (0.49) | 0.0457 | 0.51 (0.51) | 0.0097 | ||
| N positivity | 2.51 (0.50) | 0.0004 | 2.21 (0.57) | 0.0062 | 2.09 (0.69) | 0.034 |
| NKI-295 dataset | ||||||
| Univariate analysis |
Multivariate analysis |
Multivariate analysis in ER-positive |
||||
| Variable |
HRb (95% CIc±) |
p-value |
HRb (95% CIc±) |
p-value |
HRb (95% CIc±) |
p-value |
| AIRE positivity | 0.63 (0.41) | 0.0260 | 0.54 (0.42) | 0.0039 | 0.52 (0.54) | 0.0168 |
| Tumor size >2 cm | 1.71 (0.37) | 0.0041 | 1.41 (0.38) | 0.0772 | 1.43 (0.45) | 0.1221 |
| ER positivity | 0.51 (0.39) | 0.0006 | 0.59 (0.43) | 0.0165 | ||
| Grade III | 2.02 (0.36) | 0.0002 | 1.65 (0.41) | 0.0178 | 1.92 (0.46) | 0.0054 |
| KM-Plotter | ||||||
| Univariate analysis |
Multivariate analysisd |
Multivariate analysis in ER-positived |
||||
| Variable |
HRb (95% CIc±) |
p-value |
HRb (95% CIc±) |
p-value |
HRb (95% CIc±) |
p-value |
| AIRE positivity | 0.83 (0.13) | 0.0033 | 0.84 (0.74–0.96) | 0.0081 | 0.79 (0.65–0.97) | 0.0221 |
| ESR1 positivitye | 0.65 (0.12) | <10−6 | 0.64 (0.56–0.74) | <10−16 | ||
| MKI67 positivitye | 1.43 (0.11) | <10−6 | 1.25 (1.1–1.42) | 0.0033 | 1.4 (1.16–1.69) | 0.0005 |
a
Multivariate Cox proportional hazards regression analysis was performed using WinSTAT version 2009.1 for Microsoft Excel with direct elimination, and all predictors significantly associated with prognosis in univariate analysis (p < 0.05) were considered.
b
Hazard ratio (HR) estimated from Cox proportional hazard regression model.
c
Confidence interval of the estimated HR.
d
Multivariate analysis of this data set was performed online on KM-Potter website considering AIRE expression and that of the only available covariates: ESR1 and MKI67 expression.
e
median expression cut-off.