Table 1. Activity of the top 30 active hits that had good activity (better than current clinical drugs) against stationary phase B. burgdorferia.
Seven-day-old stationary phase B. burgdorferi culture was treated with drugs or compounds (50 μM) for seven days, at which point the viability of the bacteria was determined, as previously described12.
The NSC number is a numeric identifier for substances submitted to the NCI.
Residual viable B. burgdorferi was calculated according to the regression equation and the ratio of Green/Red fluorescence obtained by the SYBR Green I/PI assay, as previously described12.
Residual viable B. burgdorferi was assayed by epifluorescence microscope counting, as previously described12.