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. 2015 Jun 3;4(6):e31. doi: 10.1038/emi.2015.31

Table 3. Comparison of the activity of some hit compounds at 20 μM and 50 μM against stationary phase B. burgdorferia.

NSC number Compounds Residual viable cells (%)
20 μMb 20 μMc 50 μMc
258812 Control 93 94 95
Amoxicillin 77 77 77
Doxycycline 76 77 77
Daptomycin 32 25 18
Dimethyldaunomycin hydrochloride 0 10 10
363998 Anthracene-9,10-dione, 1,5-bis[3-[[(2-hydroxyethyl)amino] propyl]amino]-9,10-dihydro-, dihydrochloride 22 14 13
70845 Nogalamycin 3 15 15
267229 Pyrromycin 6 20 21
136044 Rhodomycin A 5 21 21
345647 Chaetochromin 31 33 22
47147 Prodigiosin 0 45 24
267461 Nanaomycin 39 45 26
659997 Naphthalene-1,4-dione, 2-chloro-5,8-dihydroxy-3-(2-methoxyethoxy)- 40 50 28
224124 (5,8-dihydroxy-1,4-dioxo-1,4-dihydronaphthalene-2,3-diyl)dimethanediyl dicarbamate 54 77 31
617570 Benzoic acid, 2-hydroxy-, (2,6-pyridinediyldiethylidyne) dihydrazide, nickel complex 66 50 38
93739 2-Methyl-4,4′-[(4-imino-2,5-cyclohexadien-1-ylidene)methylene]dianiline hydrochloride 0 77 43
a

Seven-day-old stationary phase B. burgdorferi culture was treated with drugs for seven days.

b

Residual viable B. burgdorferi was calculated according to the regression equation and the ratio of Green/Red fluorescence obtained by the SYBR Green I/PI assay.

c

Residual viable B. burgdorferi was assayed by epifluorescence microscope counting.