Figure 2.

Sequence alignment of IL37 proteins from multiple species. Three major IL37 variant sequences identified in 1000 Genomes samples and 11 non-human mammalian orthologous sequences (10 primates and Canis) were aligned by Clustal-omega. Nucleotide positions identical to human reference IL37 sequence are indicated as dots. Grey bars under the sequence alignment depict the conservation profile of the corresponding amino-acid residues, with 100 indicates complete conservation. Shaded regions correspond to predicted secondary structure of β-sheet in 3D protein structure (right panel), which constitute the basic structural framework of IL-1 family members. The cartoon view in the right panel with predicted 3D protein structure of IL37 was created by SWISS-MODEL (http://swissmodel.expasy.org).