Table 1.
Baseline Characteristics of Participants Stratified by Troponin Concentration Quarters
| All (N = 3,318) |
Quarters of Troponin I Concentration |
p Value Trend | ||||
|---|---|---|---|---|---|---|
| Q1 (n = 748) |
Q2 (n = 889) |
Q3 (n = 843) |
Q4 (n = 838) |
|||
| Troponin concentration, ng/l | ≤3.1 | 3.1–3.9 | 4.0–5.1 | ≥5.2 | ||
| Age, yrs | 55.1 ± 5.5 | 53.8 ± 5.2 | 55.0 ± 5.5 | 55.4 ± 5.5 | 56.2 ± 5.5 | <0.001 |
| Body mass index, kg/m2 | 25.9 ± 3.2 | 25.6 ± 3.2 | 25.9 ± 3.0 | 26.0 ± 3.1 | 26.3 ± 3.3 | <0.001 |
| Employed | 2,346 (71) | 577 (77) | 637 (72) | 612 (73) | 520 (62) | <0.001 |
| Smoking and alcohol status | ||||||
| Current smoker | 1,393 (42) | 333 (45) | 393 (44) | 343 (41) | 324 (39) | 0.043 |
| Alcohol intake, ≥21 U/week | 546 (17) | 121 (16) | 158 (18) | 138 (16) | 129 (15) | 0.603 |
| Blood pressure and heart rate | ||||||
| Systolic, mm Hg | 136 ± 17 | 133 ± 17 | 134 ± 17 | 136 ± 18 | 139 ± 18 | <0.001 |
| Diastolic, mm Hg | 84 ± 11 | 83 ± 11 | 84 ± 11 | 84 ± 10 | 85 ± 11 | <0.001 |
| Heart rate, beats/min | 65 ± 11 | 67 ± 11 | 66 ± 11 | 65 ± 11 | 65 ± 12 | <0.001 |
| Past medical history | ||||||
| Hypertension | 544 (16) | 87 (12) | 122 (14) | 138 (16) | 197 (24) | <0.001 |
| Diabetes mellitus | 36 (1) | 8 (1) | 9 (1) | 10 (1) | 9 (1) | 0.988 |
| Angina∗ | 168 (5) | 23 (3) | 35 (4) | 48 (6) | 62 (7) | <0.001 |
| Intermittent claudication | 82 (3) | 20 (3) | 16 (2) | 18 (2) | 28 (3) | 0.186 |
| Minor ECG abnormalities∗ | 271 (8) | 36 (5) | 62 (7) | 63 (8) | 110 (13) | <0.001 |
| Family history of CHD death | 191 (6) | 44 (6) | 46 (5) | 42 (5) | 59 (7) | 0.256 |
| Medication | ||||||
| Nitrate | 74 (2) | 8 (1) | 14 (2) | 18 (2) | 34 (4) | <0.001 |
| Beta-blocker | 241 (7) | 38 (5) | 46 (5) | 67 (8) | 90 (11) | <0.001 |
| ACE inhibitor | 36 (1) | 4 (1) | 11 (1) | 8 (1) | 13 (2) | 0.246 |
| Lipid levels | ||||||
| Total cholesterol, mg/dl | 270 ± 22 | 268 ± 22 | 270 ± 22 | 272 ± 22 | 272 ± 22 | <0.001 |
| LDL cholesterol, mg/dl | 191 ± 17 | 188 ± 16 | 190 ± 17 | 193 ± 17 | 193 ± 18 | <0.001 |
| HDL cholesterol, mg/dl | 44 ± 9 | 43 ± 9 | 44 ± 10 | 44 ± 9 | 43 ± 9 | 0.666 |
| Triglycerides, mg/dl | 154 ± 136 | 159 ± 138 | 151 ± 134 | 154 ± 136 | 154 ± 136 | 0.249 |
| Treatment allocation | ||||||
| Placebo | 1,647 (50) | 385 (51) | 456 (51) | 392 (47) | 414 (49) | 0.150 |
| Pravastatin 40 mg | 1,671 (50) | 363 (49) | 433 (49) | 451 (53) | 424 (51) | 0.150 |
Values are mean ± SD or n (%).
ACE = angiotensin-converting enzyme; CHD = coronary heart disease; ECG = electrocardiogram; HDL = high-density lipoprotein; LDL = low-density lipoprotein; Q = quarter.
∗
Symptoms consistent with angina on Rose questionnaire and minor ST-segment or T-wave abnormalities on resting 12-lead ECG defined by Minnesota codes (4-2, 4-3, 5-2, 5-3).