Table 1.
Recent and current clinical trials in pancreatic cancer (further information can be found at www.cancerhelp.org.uk/trials/trials/)
Trial | Phase | Details | Recruitment dates or results |
---|---|---|---|
GEM-CAP |
III |
Single or combination therapy. Comparing gemcitabine alone with a combination of gemcitabine and capecitabine |
April 2002 to March 2005 |
ESPAC 1 |
III |
Compared survival in tumour resected patients having chemoradiotherapy, a combination of chemoradiotherapy and chemotherapy, and no adjuvant treatment |
Recently concluded trial showed adjuvant chemotherapy had a significant beneficial effect on survival, whereas chemoradiotherapy had a deleterious effectw13 |
ESPAC 3 v2 |
III |
Comparing gemcitabine with a combination of fluorouracil and folinic acid |
July 2000 to July 2005 |
MetXia-OB83 and cyclophosphamide | I | Patients will be given a combination of MetXia-OB83 (gene therapy) and cyclophosphamide | March 2004 to October 2005 |