Table 1.
Hypoxia primed adult stem cells for chondrogenesis.
| MSC | Passage | O2 % | Proliferation | Chondro- | others | References |
|---|---|---|---|---|---|---|
| hASC | 1 | 1,5,10,15 | ↑ CFU-F | ↓ (pellet) | - | 44 |
| hASC | 3 | 2 vs 21 | ↑ stemness/cell number; ↓ PDT |
↑ (pellet) | ↓ osteo- /adipo- |
34 |
| mASC | 2 | 2 vs 21 | ↑ cell number/BrdU; ↓ PDT |
↑ (pellet) | ↓ osteo- | 35 |
| hBMSC | 2 | 3 vs 21 | ↑ number of cell colonies | ↑ (pellet) | - | 42 |
| hBMSC | - | 4 vs 20 | - | ↑ (pellet/gelatin/gelatin+HA) |
- | 41 |
| hBMSC | 2 | 5 vs 21 | ↑ CFU-F/cell number | ↑ (pellet) (ns) | osteo- (nc); ↓ adipo- (ns) |
38 |
| hBMSC | 4 | 1.5 vs 21 | ↑ cell number | ↑ (pellet) | nc | 39 |
| oBMSC | 2 | 5 vs 20 | ↑ CFU-F; ↓β-gal/cell size |
↑ (pellet/collagen I hydrogel) |
- | 37 |
| oBMSC | 2 | 5 vs 20 | ↑ number and size of cell colonies |
↑ (pellet) | - | 36 |
| hIFPSC | 2 | 5 vs 20 | - | ↑ (pellet) | - | 45 |
| gDSC | - | 5 vs 20 | ↓ cell number/CFU-F | ↑ (pellet) | - | 40 |
| pSDSC | 3 | 5 vs 21 | ↑ cell number; ↓ cell size |
nc | - | 43 |
| hUCB CD133(+) |
1 | 1.5 vs 21 | ↑ clonogenic myeloid capacity | - | - | 39 |
Abbreviation: CFU-F: colony forming unit-fibroblast; DSCs: dermis isolated stem cells; g: goat; h: human; HA: hyaluronan; nc: no change; ns: no significant difference; o: ovine/sheep; p: porcine; PDT: population doubling time; stemness markers: REX1, SOX2, OCT4, and NANOG; UCB: umbilical cord blood