Table 2.
Growth factor primed stem cells for chondrogenesis.
| MSC | Passage | Dose (ng/mL) | Proliferation | Chondro- | Adipo- /osteo- |
Reference |
|---|---|---|---|---|---|---|
| mASC | 1 | 5, 10, 50, 100 (F) | ↑ cell number | ↑ (pellet) | - | 86 |
| hBMSC | 2–4 | 10 (F) | ↑ growth index | ↑ (pellet) | No difference | 87 |
| hBMSC | 1–7 | 10 (F) | ↑ PD | ↑ (pellet) | - | 95 |
| hBMSC | 2–4 | 1, 10 (F) | n/a | ↑ (pellet) | - | 165 |
| hBMSC | - | 1, 5, 10 (F) | ↓ cell size & PDT | ↑ (pellet) | - | 92 |
| hBMSC | 2 | 5 (F) | - | ↑ (pellet) | - | 106 |
| hBMSC | - | 1 (F) | ↑ TRF length; ↓ PDT |
↑ (pellet) | - | 89 |
| hBMSC | 1–2 | 10 (F) | - | ↑ (pellet) | 108 | |
| hBMSC | 1 | 1 (F) | ↑ colony size; ↓ colony number |
↑ (pellet) | ↑ osteo- | 85 |
| hBMSC | - | 1 (F) | ↑ PD | ↑ (pellet) | - | 101 |
| hIFPSC | 2 | 10 (F) | ↑ cell number | ↑ (pellet) | - | 88 |
| pIFPSC | 1–2 | 5 (F) | ↓ PDT | ↑ (agarose hydrogel) |
- | 96 |
| bSDSC | 4 | 1 (T) + 5 (F) + 10 (P) | - | ↑ (agarose disc) |
- | 97 |
| dSDSC | 2 | 1 (T) + 5 (F) + 10 (P) | ↓ PDT | ↑ (pellet) | - | 107 |
| hSDSC | 1–2 | 0.1, 1, 10, 100 (F) | ↓ cell size; ↑ cell number |
↑ (pellet) | - | 91 |
| pSDSC | 3 | 10 (T) + 50 (F) + 500 (I) | - | ↑ (pellet) | - | 166 |
| pSDSC | 3 | 10 (F) | ↑ cell number; ↓ cell size |
↑ (pellet); hypertrophy |
- | 43 |
Abbreviation: ASCs: adipose stem cells; BMSCs: bone marrow stromal cells; b: bovine; d: dog; F: basic fibroblast growth factor; h: human; I: insulin-like growth factor I; IFPSCs: infrapatellar fat pad derived stem cells; m: mouse; p: porcine; P: platelet-derived growth factor-BB; PD: population doubling; PDT: population doubling time; SDSCs: synovium-derived stem cells. TRF: telomere restriction fragment; T: transforming growth factor beta 1