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. Author manuscript; available in PMC: 2018 Jan 1.
Published in final edited form as: Obstet Gynecol. 2017 Jan;129(1):121–129. doi: 10.1097/AOG.0000000000001774

Figure 1.

Figure 1

Flow diagram of the Women's Health Initiative (WHI) trials of menopausal hormone therapy (HT) and calcium plus vitamin D (CaD). There were 27,347 women randomized in the menopausal HT trials, and 16,089 participants were also randomized in the CaD trial. Of these, 1,521 were part of the blood subsample and included in this analysis. *The WHI clinical trial used a partial fractional design, so not all HT trial participants were later randomized to CaD; details have been previously published.1 Among the 16,089 participants in the WHI-CaD trail, 5,017 were also a part of the WHI-DM cohort.