Table 1.
Participant Demographics
| Demographic Variable | Cognitively Normal (CN) (n=70) | Subjective Cognitive Concerns (SCC)(n=74) | Mild Cognitive Impairment (MCI) (n=29) | Probable/Pos sible AD (n=10) | p-value |
|---|---|---|---|---|---|
| Mean Age (SE)a | 75 (1.01) | 77 (0.93) | 80 (1.52) | 77 (2.60) | 0.045 |
| Mean Education (SE) | 17 (0.26) | 16 (0.29) | 16 (0.48) | 15 (1.05) | 0.47 |
| Sex (% female) | 71% | 59% | 48% | 40% | 0.07 |
| ApoE4 Status (%+4)* | 24% | 23% | 40% | 100% | 0.0002 |
| Mean CDR-SOB (SE)**, b | 0.01 (0.01) | 1.02 (0.08) | 1.52 (0.18) | 4.50 (0.19) | <0.0001 |
| Mean MMSE Score (SE)***c | 29.45 (0.10) | 28.95 (0.16) | 27.62 (0.28) | 24.71 (1.32) | <0.0001 |
| Mean BNT Score (SE)***d | 28.66 (0.20) | 27.99 (0.25) | 26.76 (0.74) | 24.43 (1.66) | 0.0036 |
| Mean Trails B Time (SE)†e | 62.43s (3.2s) | 75.66s (3.95s) | 109.03s (9.04s) | 167.00s (29.14s) | <0.0001 |
| Mean OAS Sum Score (SE)‡ | 69 (1.04) | 71 (1.21) | 71 (1.82) | 70 (4.70) | 0.53 |
Overall p value from one-way ANOVA. Significant pairwise difference between CN and MCI (p<0.05).
Overall p value from Kruskal-Wallis test. All pairwise differences between diagnoses are significant (p<0.02)
Overall p value from Kruskal-Wallis test. Significant pairwise differences between CN and SCC (p<0.03), CN and MCI (p<0.0001), CN and AD (p<0.02), SCC and MCI (p<0.0001), and SCC and AD (p<0.01)
Overall p value from Kruskal-Wallis test. Significant pairwise difference between CN and AD (p<0.02)
Overall p value from one-way ANOVA on transformed scale. Significant pairwise differences (on transformed scale) between CN and AD (p<0.0001), SCC and MCI (p<0.001), SCC and AD (p<0.001), CN and SCC (p<0.02), and CN and MCI (p<0.0001)
For this measure, n=67 for CN, n=66 for SCC, n=25 for MCI, and n=7 for Probable/Possible AD.
For this measure, n=70 for CN, n=73 for SCC, n=29 for MCI, and n=9 for Probable/Possible AD.
For this measure, n=67 for CN, n=73 for SCC, n=28 for MCI, and n=7 for Probable/Possible AD.
For this measure, n=67 for CN, n=73 for SCC, n=28 for MCI, and n=6 for Probable/Possible AD.
For this measure, n=70 for CN, n=73 for SCC, n=29 for MCI, and n=10 for Probable/Possible AD.
Abbreviations: Cognitively Normal (CN), Subjective Cognitive Concerns (SCC), MCI = mild cognitive impairment, AD = Alzheimer’s disease, SE = standard error of the mean, CDR-SOB = clinical dementia rating-sum of boxes, MMSE = mini mental status examination, BNT = Boston Naming Test, OAS = Odor Awareness Scale.