Figure 2.

Axial and coronal T1 and T2 MRI images illustrating wide range of dysplastic megalencephaly resulting from the mosaic nature of the disorder. Image A shows gyral enlargement and blurring of cortical-white matter junction (arrows) affecting the left temporal lobe (localized megalencephaly). Image B shows right hemisphere dysgenesis with dilation of the right lateral ventricle, anterior pachygyria (small white arrows), posterior lissencephaly (large white arrows), very dysmorphic basal ganglia (in center of hemisphere) and regions of abnormal white matter (black arrows). Image C shows pachygyric frontal cortex in the affected right hemisphere (large white arrows) with multiple areas of white matter hyperintensity (small white arrows), impaired myelination (relatively hyperintense white matter), and epsilateral dysmorphic ventriculomegaly. Image D shows enlarged, dysmorphic right cerebellar hemisphere (cerebrum of this patient not shown).