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. 2016 Dec 22;10:282. doi: 10.3389/fncel.2016.00282

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Copyright © 2016 Gu, Bao, Chen, Huang, Zhang, Jiang, Liu, Liu, Xu and Shi.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Ideograph of the NP847-Sox2 complex-mediated enhancement of NSC self-renewal by increasing the expression of Shh. CaMKII phosphorylates nNOS at ser847, and then the NP847-Sox2 complex enhances the transcription of Shh. CaMKII, calcium-calmodulin-dependent protein kinase II; Ptch1, Patched 1; Smo, smoothened.